Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis.
Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely neflintw-r6mpw unknown.We evaluated inflammatory and fibrosis responses to bleomycin in F508del homozygous and wild-type mice, and phenotype of fibrob